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However, disruption of other mitochondrial enzymes/complexes of cerebral energy metabolism (e.g., α-ketoglutarate dehydrogenase complex (KGDHC) and pyruvate dehydrogenase complex (PDHC)) may also contribute to decreased energy production in neurodegenerative disease (reviewed by Gibson et al., 2005, Kiss et al., 2013)

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1-3 Glutathione is also involved in the metabolism of certain compounds that can increase free radical activity